1002754-27-9合成路线 （共 11 条）
反应条件
1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C 2: NaBH4 / CH2Cl2; methanol / -78 °C 3: pyridine; DMAP / CH2Cl2 / 20 °C 4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C 5: TBAF / tetrahydrofuran / 20 °C 6: triethylamine / CH2Cl2 7: N-methylmorpholine N-oxide; water / OsO4 / 2-methyl-propan-2-ol; acetone 8: H2 / Pd(OH)2/C / ethanol / 20 °C / 5171.48 Torr View Scheme
参考文献
Guo, Haibing; O'Doherty, George A.
Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 7 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C5: TBAF / tetrahydrofuran / 20 °C6: triethylamine / CH2Cl2 7: N-methylmorpholine N-oxide; water / OsO4 / 2-methyl-propan-2-ol; acetone
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 4 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 6 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C5: N-methylmorpholine N-oxide; water / OsO4 / 2-methyl-propan-2-ol; acetone6: para-toluenesulfonic acid monohydrate / acetone / 0 °C
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 3 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 5 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C5: N-methylmorpholine N-oxide; water / OsO4 / 2-methyl-propan-2-ol; acetone
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 7 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C5: N-methylmorpholine N-oxide; water / OsO4 / 2-methyl-propan-2-ol; acetone6: para-toluenesulfonic acid monohydrate / acetone / 0 °C7: TBAF / tetrahydrofuran / 20 °C
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 8 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C5: N-methylmorpholine N-oxide; water / OsO4 / 2-methyl-propan-2-ol; acetone6: para-toluenesulfonic acid monohydrate / acetone / 0 °C7: TBAF / tetrahydrofuran / 20 °C8: triethylamine / CH2Cl2 / 0 °C
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 5 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C5: TBAF / tetrahydrofuran / 20 °C
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
反应条件
Multi-step reaction with 6 steps 1: Pd2(DBA)3*CHCl3; triphenylphosphine / CH2Cl2 / 0 - 20 °C2: NaBH4 / CH2Cl2; methanol / -78 °C3: pyridine; DMAP / CH2Cl2 / 20 °C4: TMSN3 / allylpalladium chloride dimer; 1,4-bis(diphenylphosphino)butane / tetrahydrofuran / 50 °C5: TBAF / tetrahydrofuran / 20 °C6: triethylamine / CH2Cl2
参考文献
Guo, Haibing; O'Doherty, George A. Organic Letters, 2006 , vol. 8, # 8 p. 1609 - 1612
