6,7,8-三氟-1-(甲酰基甲基氨基)-1,4-二氢-4-氧代-3-喹啉羧酸乙酯合成路线 （共 4 条）
反应条件
triethylamine in 1-methyl-pyrrolidin-2-one T=100°C; 3 h; Product distribution / selectivity;
参考文献
WO2011/61292 A1, ;
Page/Page column 43-44 ;
参考文献
KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO; ZUPET, Rok; ISKRA, Jernej; RUZIC, Milos; PECAVAR, Anica; KOLENC, Ivanka; PUCELJ, Joze; PLAPER, Igor
Patent: WO2011/61292 A1, 2011 ;
Location in patent: Page/Page column 43-44 ;
反应条件
With sodium carbonate in 1-methyl-1-formyl-hydrazine; toluene Show Experimental Procedure
参考文献
Pfizer. Inc Patent: US5892040 A1, 1999 ;
反应条件
With NAF in N,N-dimethyl-formamide T=140 - 150°C; 2 h;
参考文献
Grohe, Klaus; Heitzer, Helmut Liebigs Annalen der Chemie, 1987 , p. 871 - 880
