1: 95 percent / silver zeolite / CH2Cl2 / 1 h / Ambient temperature 2: 85 percent / sodium methoxide / methanol 3: 85 percent / p-toluenesulphonic acid / acetonitrile 4: 86 percent / sodium hydride / 1,2-dimethoxy-ethane 5: 95 percent / molecular sieves, sodium cyanoborohydride, HCl / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature 6: 46 percent / collidine, silver triflate / nitromethane / 1.) -25 deg C, 4 h; 2.) rt, overnight 7: 1.) hydrazine hydrate / 1.) 95percent aqueous ethanol, reflux, 30 min; 2.) pyridine, rt, overnight 8: 87 percent / hydrogen / palladium-on-carbon / methanol / 16 h View Scheme

1: 95 percent / silver zeolite / CH2Cl2 / 1 h / Ambient temperature 2: 85 percent / sodium methoxide / methanol 3: 85 percent / p-toluenesulphonic acid / acetonitrile 4: 86 percent / sodium hydride / 1,2-dimethoxy-ethane 5: 95 percent / molecular sieves, sodium cyanoborohydride, HCl / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature 6: 46 percent / collidine, silver triflate / nitromethane / 1.) -25 deg C, 4 h; 2.) rt, overnight 7: 1.) hydrazine hydrate / 1.) 95percent aqueous ethanol, reflux, 30 min; 2.) pyridine, rt, overnight 8: 87 percent / hydrogen / palladium-on-carbon / methanol / 16 h 9: 65 percent / tetraethylammonium bromide, molecular sieves / CH2Cl2; dimethylformamide / 16 h / Ambient temperature 10: 1.) hydrogen; 2.) sodium methoxide / 1.) palladium-on-carbon / 1.) methanol, 16 h; 2.) methanol View Scheme

1: 95 percent / silver zeolite / CH2Cl2 / 1 h / Ambient temperature 2: 85 percent / sodium methoxide / methanol 3: 85 percent / p-toluenesulphonic acid / acetonitrile 4: 86 percent / sodium hydride / 1,2-dimethoxy-ethane 5: 88 percent / 60percent aqueous acetic acid / 0.5 h / 100 °C 6: 42 percent / tetraethylammonium bromide, molecular sieves / CH2Cl2 / 6 h / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: 88 percent / silver trifluoromethanesulfonate, 2,4,6-trimethylpyridine / nitromethane / 2 h / -30 °C2: 97 percent / conc. hydrochloric acid / H2O; acetone / 6 h / 70 °C  

Multi-step reaction with 4 steps 1: 1.) silver trifluoromethanesulfonate, 2,4,6-trimethylpyridine, molecular sieves type 4A / 1.) dichloromethane, r.t., 1 h; 2.) dichloromethane, 4 h2: 89.9 percent / 60 percent acetic acid / H2O / 1.5 h / 85 °C3: 1.) 85 percent hydrazine hydrate / 1.) ethanol, 70 deg C, 15 min; 2.) pyridine, 90 deg C, 20 min4: 88.9 percent / 0.1 M sodium methoxide / methanol / 1.) r.t., 2 h; 2.) in refrigerator, 2 h  

Multi-step reaction with 3 steps 1: 1.) silver trifluoromethanesulfonate, 2,4,6-trimethylpyridine, molecular sieves type 4A / 1.) dichloromethane, r.t., 1 h; 2.) dichloromethane, 4 h2: 89.9 percent / 60 percent acetic acid / H2O / 1.5 h / 85 °C3: 1.) 85 percent hydrazine hydrate / 1.) ethanol, 70 deg C, 15 min; 2.) pyridine, 90 deg C, 20 min  

Multi-step reaction with 2 steps 1.1: sodium methoxide; triethylamine / H2O; methanol / 1.5 h / 50 °C1.2: 68 percent / pyridine / 20 - 100 °C2.1: hydrogen bromide / acetic acid / 1.5 h / 20 °C  

Multi-step reaction with 3 steps 1: 54 percent / silver zeolite / CH2Cl2 / 40 h / Ambient temperature2: 99 percent / methanol / 0.5 h3: 64 percent / p-TsOH*H2O / acetonitrile / 0.83 h / Ambient temperature  

With  2,3,5-trimethyl-pyridine; silver trifluoromethanesulfonate in  nitromethane  1) -25 deg C, 30 min, 2) RT, 4.5 h;   

Multi-step reaction with 6 steps 1: 54 percent / silver zeolite / CH2Cl2 / 40 h / Ambient temperature2: 99 percent / methanol / 0.5 h3: 64 percent / p-TsOH*H2O / acetonitrile / 0.83 h / Ambient temperature4: 90 percent / 1) NaH / tetrahydrofuran / 21 h / Ambient temperature5: 1) sodium cyanoborohydride, mol. sieves 3A, 2) TFA / 1) DMF, 15 min, RT, 2) DMF, 43 h6: 66 percent / silver triflate, collidine / nitromethane / 1) -25 deg C, 30 min, 2) RT, 4.5 h