反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C
2.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice
3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
3.2: 0.5 h / Reflux
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; MAYNARD, Andy; MILLER, John; PATTERSON, Dan; PEAT, Andrew, James; POWERS, Jeremiah; PRICE, Daniel, J.; ROBERTS, Chris; TAI, Vincent; YOUNGMAN, Michael
Patent: WO2011/50284 A1, 2011 ;