1: 1H-pyrrole-2-carboxaldehyde With sodium hydride in N,N-dimethyl-formamide
T=0°C; 1.5 h;
2: 1-ethoxy-2-bromoethane in DMF (N,N-dimethyl-formamide)
T=0 - 50°C; 2.75 h;
3: With ammonium chloride in DMF (N,N-dimethyl-formamide); water
T=20°C;
参考文献
Tularik Inc.
Patent: US2003/229093 A1, 2003 ;
Location in patent: Page 42 ;
US 20030229093 A1
