1: 2-thienyl halide With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 2 h; 2: thiophene-2-carbonitrile in tetrahydrofuran 3 h; Further stages. Title compound not separated from byproducts.;
1: With diisobutylaluminium hydride in toluene T=20°C; 0.222222 h; Flow reactor; 2: With water; tartaric acid disodium salt in toluene T=0°C; chemoselective reaction;
参考文献
Munoz, Juan De M.; Alcazar, Jesus; De La Antonio, Hoz; Diaz-Ortiz, Angel
Tetrahedron Letters, 2011 , vol. 52, # 46 p. 6058 - 6060
1: With sodium hydride; tert-butyl alcohol in diethyl ether Guareschi-Thorpe type condensation; 7 h; Reflux; 2: With hydrogenchloride; water in ethanol T=20°C; 0.5 h;
参考文献
Puterova, Zita; Andicsova, Anita; Vegh, Daniel
Tetrahedron, 2008 , vol. 64, # 49 p. 11262 - 11269
