反应条件
1.1: nitric acid; sulfuric acid / 3 h / 100 - 105 °C
2.1: N,N-dimethyl-formamide / 1.5 h / 100 °C
3.1: palladium 10 on activated carbon; hydrogen / ethanol / 8 h / 20 - 65 °C / 1500.15 - 2250.23 Torr / |Inert atmosphere; |Autoclave
4.1: AlCl3, aluminium chloride / dichloromethane / 0.5 h / 0 °C / |Inert atmosphere
4.2: 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Ganser, Christopher; Lauermann, Eva; Maderer, Annett; Stauder, Torsten; Kramb, Jan-Peter; Plutizki, Stanislav; Kindler, Thomas; Moehler, Markus; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9531 - 9540