2,4,5-三溴-1-甲基-1H-咪唑合成路线 (共 13 条)
反应条件
n-butyllithium in tetrahydrofuran T=-70°C; 1.5 h;
参考文献
Shapiro; Gomez-Lor
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5524 - 5526
反应条件
ethylmagnesium bromide in diethyl ether 3 h; Ambient temperature;
参考文献
O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry
Synthesis, 1988 , # 10 p. 767 - 771
反应条件
sodium sulfite 24 h; Reflux;
参考文献
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; PROVID PHARMACEUTICALS INC.; EBRIGHT, Richard H.; EBRIGHT, Yon W.; SHEN, Juan; BACCI, James; HIEBEL, Anne-Cecile; SOLVIBILE, William; SELF, Christopher; OLSON, Gary
Patent: WO2013/192352 A1, 2013 ;
Location in patent: Page/Page column 117 ;