(5-乙酰氧基-6-甲基-3,4-吡啶二基)二(亚甲基)二乙酸酯合成路线 （共 4 条）
反应条件
triethylamine in tert-butyl methyl ether T=50 - 65°C; 2.5 h; Industry scaleHeating / reflux;
参考文献
BIOSTRATUM, INC.
Patent: WO2005/77902 A2, 2005 ;
Location in patent: Page/Page column 34-35 ;
反应条件
1: in DMF (N,N-dimethyl-formamide) T=55°C; 1 h; 2: With sodium acetate T=85°C; 4 h;
参考文献
DSM IP ASSETS B.V.
Patent: WO2005/90356 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
triethylamine Heating / reflux;
参考文献
BIOSTRATUM, INC.
Patent: WO2005/77902 A2, 2005 ;
Location in patent: Page/Page column 18 ;
反应条件
hydrogenchloride in water 2 h; Heating;
参考文献
Geiger; Lalonde; Stoller; Schleich
Helvetica Chimica Acta, 1984 , vol. 67, # 5 p. 1274 - 1282
