(S)-(-)-3-氯-1-苯基-1-丙醇合成路线 （共 28 条）
反应条件
1: 70 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature 2: 95 percent / ethanol; H2O / 3 h / 130 °C View Scheme
参考文献
Srebnik, Morris; Ramachandran, P.V.; Brown, Herbert C.
Journal of Organic Chemistry, 1988 , vol. 53, # 13 p. 2916 - 2920
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: sodium iodide / dimethyl sulfoxide / 13 h / 70 °C 3.1: hydrazine hydrate / methanol; dichloromethane / 8 h / 20 °C View Scheme
参考文献
Cashman, John R.; Voelker, Troy; Johnson, Robert; Janowsky, Aaron
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 337 - 343
反应条件
1: 100 percent / NaI / acetone / Heating 2: 85 percent / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Robertson; Krushinski; Fuller; Leander
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1412 - 1417
反应条件
sodium iodide in water
参考文献
Schneider; Goergens
Tetrahedron Asymmetry, 1992 , vol. 3, # 4 p. 525 - 528
反应条件
1: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature 2: 90 percent / ethanol; H2O / 3 h / 130 °C View Scheme
参考文献
Srebnik, Morris; Ramachandran, P.V.; Brown, Herbert C.
Journal of Organic Chemistry, 1988 , vol. 53, # 13 p. 2916 - 2920
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran Mitsunobu reaction;
参考文献
Lapis, Alexandre A. M.; De Fatima, Angelo; Martins, Jose E. D.; Costa, Valentim E. U.; Pilli, Ronaldo A.
Tetrahedron Letters, 2005 , vol. 46, # 3 p. 495 - 498
反应条件
triphenylphosphine in tetrahydrofuran; pentane
参考文献
Aldrich-Boranes, Inc.
Patent: US4868344 A1, 1989 ;
反应条件
1: (S)-(-)-3-chloro-1-phenyl-1-propanol; dimethyl amine With potassium iodide in ethanol
T=55 - 60°C; 7 h;
2: With sodium hydroxide in toluene
pH=11 - 12;
3: oxalic acid in ethyl acetate; acetone
T=20 - 25°C; 2.5 h;
参考文献
MATRIX LABORATORIES LTD; VELLANKI, Siva, Rama, Prasad; SAHU, Arabinda; KATUKURI, Aravind, Kumar; PILLI, Ramakrishna; KOTHARI, Satish, Babu; DATTA, Debashish
Patent: WO2011/27359 A2, 2011 ;
Location in patent: Page/Page column 3; 5; 12 ;
