反应条件
1: 85 percent / Et3N / CH2Cl2 / 0 °C
2: aq. TFA / tetrahydrofuran / Ambient temperature
3: Na2CO3, Pb(OAc)4 / CH2Cl2 / 0.25 h / -78 °C
4: toluene / 3 h / 80 °C
5: lithium hexamethyldisilazane (LiHMDS) / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 - 0 °C
6: NaHCO3 / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / Ambient temperature
7: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature
8: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature
View Scheme
参考文献
Leblanc, Yves; Fitzsimmons, Brian J.; Adams, Julian; Perez, Francoise; Rokach, Joshua
Journal of Organic Chemistry, 1986 , vol. 51, # 6 p. 789 - 793