1: aq. TFA / tetrahydrofuran / Ambient temperature 2: Na2CO3, Pb(OAc)4 / CH2Cl2 / 0.25 h / -78 °C 3: toluene / 3 h / 80 °C 4: lithium hexamethyldisilazane (LiHMDS) / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 - 0 °C 5: NaHCO3 / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / Ambient temperature 6: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 7: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: 68 percent / AlH3*Et2O / tetrahydrofuran / 0.5 h / 0 °C2: 85 percent / Et3N / CH2Cl2 / 0 °C  

Multi-step reaction with 2 steps 1: aq. TFA / tetrahydrofuran / Ambient temperature2: Na2CO3, Pb(OAc)4 / CH2Cl2 / 0.25 h / -78 °C  

Multi-step reaction with 3 steps 1: aq. TFA / tetrahydrofuran / Ambient temperature2: Na2CO3, Pb(OAc)4 / CH2Cl2 / 0.25 h / -78 °C3: toluene / 3 h / 80 °C