1: propanedioic acid monoethyl ester With iso-propylmagnesium bromide in tetrahydrofuran; diethyl ether T=0 - 40°C; 1.5 h; 2: imidazol-1-yl-pyridin-2-yl-methanone in tetrahydrofuran; diethyl ether T=0 - 20°C; 12 h; 3: With phosphoric acid; sodium hydrogencarbonate more than 3 stages;

1: mono-methyl malonate potassium salt With magnesium chloride in tetrahydrofuran T=65°C; 5 h; Inert atmosphere; 2: imidazol-1-yl-pyridin-2-yl-methanone in tetrahydrofuran T=30°C; 24 h; Inert atmosphere;