2-氨基-5-溴-3-硝基-4-甲基吡啶合成路线 （共 14 条）
反应条件
bromine; acetic acid T=15 - 20°C; 1.66667 - 2.25 h;
参考文献
Liu, Wansheng; Patel, Sunil S.; Cuniere, Nicolas; Lear, Yvonne; Deshpande, Prashant P.; Simon, Jeffrey N.; Lai, Chiajen; Pullockaran, Annie J.; Soundararajan, Nachimuthu; Bien, Jeffrey T.
Patent: US2007/32503 A1, 2007 ;
Location in patent: Page/Page column 8-9; 10 ;
反应条件
sulfuric acid; nitric acid
参考文献
Journal of the American Chemical Society, , vol. 79, p. 6421,6423,6424
反应条件
1: ethanol; bromine 2: concentrated H2SO4; concentrated HNO3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 6421,6423,6424
反应条件
sulfuric acid; nitric acid
参考文献
WO2012/106189 A1, ;
Page/Page column 13-14 ;
反应条件
1: chloro-trimethyl-silane; sodium nitrite 3: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran 4: hydrogen / 1 wt Pd/C / ethyl acetate View Scheme
反应条件
iron; ammonium chloride in isopropyl alcohol T=80°C; 22 h;
参考文献
Hanan, Emily J.; Chan, Bryan K.; Estrada, Anthony A.; Shore, Daniel G.; Lyssikatos, Joseph P.
Synlett, 2010 , # 18 p. 2759 - 2764
反应条件
1: hydrogenchloride; tin(ll) chloride / water / 0 - 100 °C 2: 1 h / Erfllectrochemical reaction View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1: With hydrogenchloride; tin(ll) chloride in water T=0 - 100°C; 2: With water; sodium hydroxide
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1: SnCl2; aqueous HCl 2: aqueous HCl; NaNO2 3: palladium/charcoal; platinum; aq. NaOH solution / Hydrogenation View Scheme
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
反应条件
1: methanol With acetyl chloride T=0°C; 0.166667 h; 2: 2-amino-3-nitro-4-methyl-5-bromopyridine With tert.-butylnitrite T=0 - 25°C; 5 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2006/293304 A1, 2006 ;
Location in patent: Page/Page column 29 ;
