2-氨基-5-溴-3-硝基-4-甲基吡啶合成路线 （共 14 条）
反应条件
1: With tert.-butylnitrite; acetyl chloride T=0 - 25°C; 5.66667 h; 2: With sodium hydrogencarbonate in water T=20 - 25°C; 0.25 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
1: hydrogenchloride; tin(ll) chloride / water / 0 - 100 °C 2: 1 h / Erfllectrochemical reaction 3: 10 palladium on activated carbon; platinum(IV) oxide; hydrogen; sodium hydroxide / water / 0.5 h / 2585.81 Torr View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1: chloro-trimethyl-silane; sodium nitrite
3: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran
4: hydrogen / 1 wt Pd/C / ethyl acetate
5: trichlorophosphate
6: 4-Me-2-pentanol
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
反应条件
1: chloro-trimethyl-silane; sodium nitrite
3: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
