4-溴-2-甲基吡啶 1-氧化物合成路线 （共 9 条）
参考文献
Jones, Gurnos; Pitman, Mark A.; Lunt, Edward; Lythgoe, David J.; Abarca, Belen; Ballesteros, Rafael; Elmasnaouy, Mostafa
Tetrahedron, 1997 , vol. 53, # 24 p. 8257 - 8268
反应条件
1: trifluoroacetic anhydride / dichloromethane / 0 °C 2: manganese(IV) oxide / |Reflux 3: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 20 °C 4: trifluoroacetic acid; zinc / 0 °C View Scheme
参考文献
Monnard, Fabien W.; Nogueira, Elisa S.; Heinisch, Tillmann; Schirmer, Tilman; Ward, Thomas R.
Chemical Science, 2013 , vol. 4, # 8 p. 3269 - 3274
反应条件
1: 67 percent / 1 h / 100 °C 2: 94 percent / aq. HCl / 16 h / 80 °C 3: 86 percent / DMSO, (COCl)2, Et3N / CH2Cl2 View Scheme
参考文献
Monnard, Fabien W.; Nogueira, Elisa S.; Heinisch, Tillmann; Schirmer, Tilman; Ward, Thomas R.
Chemical Science, 2013 , vol. 4, # 8 p. 3269 - 3274
反应条件
1: With trifluoroacetic anhydride in dichloromethane T=0°C; Reflux; 2: With water; sodium hydroxide in dichloromethane T=20°C; 12 h; Inert atmosphere;
参考文献
Jones, Roderick C.; Canty, Allan J.; Deverell, Jeremy A.; Gardiner, Michael G.; Guijt, Rosanne M.; Rodemann, Thomas; Smith, Jason A.; Tolhurst, Vicki-Anne
Tetrahedron, 2009 , vol. 65, # 36 p. 7474 - 7481
反应条件
1: 67 percent / 1 h / 100 °C 2: 94 percent / aq. HCl / 16 h / 80 °C 3: 86 percent / DMSO, (COCl)2, Et3N / CH2Cl2 4: 66 percent 5: 72 percent / Heating View Scheme
参考文献
Tetrahedron, , vol. 53, # 24 p. 8257 - 8268
反应条件
dihydrogen peroxide; acetic acid
参考文献
Profft; Richter
Journal fuer Praktische Chemie (Leipzig), 1959 , vol. <4> 9, p. 164,172
反应条件
acetyl-bromide; acetic acid
T=55 - 120°C;
参考文献
Jones, Roderick C.; Canty, Allan J.; Deverell, Jeremy A.; Gardiner, Michael G.; Guijt, Rosanne M.; Rodemann, Thomas; Smith, Jason A.; Tolhurst, Vicki-Anne
Tetrahedron, 2009 , vol. 65, # 36 p. 7474 - 7481
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
Patent: EP767172 A1, 1997 ;
反应条件
1: aqueous sodium nitrite; aqueous hydrobromic acid
2: acetic acid; aqueous hydrogen peroxide
View Scheme
参考文献
Profft; Richter
Journal fuer Praktische Chemie (Leipzig), 1959 , vol. <4> 9, p. 164,172
