2-溴噻唑-4-甲酸乙酯合成路线 （共 21 条）
反应条件
potassium bromide; sodium nitrite in sulfuric acid; water T=-2 - 0°C; 2 h;
参考文献
Houssin, Raymond; Pommery, Jean; Salauen, Marie-Catherine; Deweer, Sophie; Goossens, Jean-Francois; Chavatte, Philippe; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 533 - 536
反应条件
1: in ethanol T=100°C; 0.666667 h; 2: With sulfuric acid; sodium bromide; sodium nitrite; copper(II) sulfate in water T=0 - 20°C; 4 h; Further stages.;
参考文献
Wipf, Peter; Wang, Zhiyong
Organic Letters, 2007 , vol. 9, # 8 p. 1605 - 1607
反应条件
sulfuric acid; sodium bromide; sodium nitrite in water; ethyl acetate
参考文献
US2002/65308 A1, ;
US 20020065308 A1
反应条件
1: 89 percent / ethanol / 1 h / 20 - 70 °C 2: 75 percent / KBr; NaNO2 / H2O; aq. H2SO4 / 2 h / -2 - 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 2 p. 533 - 536
反应条件
potassium phosphate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=100°C; 15 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/54702 A1, 2008 ;
Location in patent: Page/Page column 112 ;
WO 2008/054702 A1
反应条件
ammonia in methanol T=50°C; 15 h;
参考文献
KARYOPHARM THERAPEUTICS, INC.; SHECHTER, Sharon; KAUFFMAN, Michael; SANDANYAKA, Vincent, P.; SHACHAM, Sharon
Patent: WO2011/109799 A1, 2011 ;
Location in patent: Page/Page column 225 ;
反应条件
N-ethyl-N,N-diisopropylamine in 1,4-dioxane Heating / reflux;
参考文献
METABOLEX INC.
Patent: WO2008/83238 A2, 2008 ;
Location in patent: Page/Page column 112 ;
WO 2008/083238 A2
反应条件
diisobutylaluminium hydride in tetrahydrofuran; dichloromethane T=-78°C; 5 h;
参考文献
Ung, Alison T.; Pyne, Stephen G.
Tetrahedron Asymmetry, 1998 , vol. 9, # 8 p. 1395 - 1407
反应条件
potassium carbonate in methanol; water T=20°C; 3 h;
参考文献
Delgado, Oscar; Martin Mueller; Bach, Thorsten
Chemistry - A European Journal, 2008 , vol. 14, # 8 p. 2322 - 2339
