2-溴噻唑-4-甲酸乙酯合成路线 （共 21 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 2.5 h; 2: With hydrogenchloride in water pH=1; Product distribution / selectivity;
参考文献
Gillespie, Paul; Goodnow, Robert Alan; Kowalczyk, Agnieszka; Le, Kang; Zhang, Qiang
Patent: US2007/167622 A1, 2007 ;
Location in patent: Page/Page column 16-17 ;
US 20070167622 A1
反应条件
lithium borohydride in tetrahydrofuran; methanol T=0 - 20°C;
参考文献
Wipf, Peter; Wang, Zhiyong
Organic Letters, 2007 , vol. 9, # 8 p. 1605 - 1607
反应条件
1: ethyl 2-bromo-4-thiazolecarboxylate With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-78°C; 2: 4-acetylmorpholine in tetrahydrofuran
参考文献
Martin, Thibaut; Laguerre, Claire; Hoarau, Christophe; Marsais, Francis
Organic Letters, 2009 , vol. 11, # 16 p. 3690 - 3693
参考文献
Gruenenthal GmbH
Patent: US2007/112011 A1, 2007 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol diethyl ether; water T=80°C; 3 h;
参考文献
WO2004/2977 A1, ;
Page 23 ;
WO 2004/002977 A1
反应条件
potassium hydroxide anschliessend Hydrieren an Raney-Nickel;
参考文献
Erlenmeyer; Morel
Helvetica Chimica Acta, 1942 , vol. 25, p. 1075
反应条件
hydrogen; palladium on activated charcoal in ethanol; water T=20°C; 12 h; atmospheric pressure;
参考文献
Houssin, Raymond; Pommery, Jean; Salauen, Marie-Catherine; Deweer, Sophie; Goossens, Jean-Francois; Chavatte, Philippe; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 533 - 536
反应条件
sulfuric acid Heating;
参考文献
Tetrahedron Letters, , vol. 36, # 30 p. 5319 - 5322
反应条件
in tetrahydrofuran Heating / reflux;
参考文献
4 SC AG
Patent: US2006/69102 A1, 2006 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With lithium hydroxide; water in tetrahydrofuran
T=20°C; 2.5 h;
2: With hydrogenchloride in water
pH=1; Product distribution / selectivity;
参考文献
Gillespie, Paul; Goodnow, Robert Alan; Kowalczyk, Agnieszka; Le, Kang; Zhang, Qiang
Patent: US2007/167622 A1, 2007 ;
Location in patent: Page/Page column 16-17 ;
US 20070167622 A1
