2-溴-4-氟-6-甲基苯甲酸合成路线 （共 5 条）
反应条件
sulfuric acid; sodium nitrite in water T=80°C;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; PAPEO, Gianluca Mariano Enrico; KRASAVIN, Mikhail Yurievitch; ORSINI, Paolo; SCOLARO, Alessandra
Patent: WO2014/64149 A1, 2014 ;
Location in patent: Page/Page column 27; 28 ;
反应条件
1.1: N-bromosuccinmide / N,N-dimethyl-formamide / 20 °C 2.1: hydrogenchloride; copper(l) chloride / toluene; water / 0 °C / Heating 2.2: 2 - 70 °C / pH 7 3.1: sulfuric acid / water / 15 h / 150 °C 4.1: sodium nitrite; sulfuric acid / water / 80 °C View Scheme
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; PAPEO, Gianluca Mariano Enrico; KRASAVIN, Mikhail Yurievitch; ORSINI, Paolo; SCOLARO, Alessandra
Patent: WO2014/64149 A1, 2014 ;
反应条件
1.1: hydrogenchloride; copper(l) chloride / toluene; water / 0 °C / Heating 1.2: 2 - 70 °C / pH 7 2.1: sulfuric acid / water / 15 h / 150 °C 3.1: sodium nitrite; sulfuric acid / water / 80 °C View Scheme
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; PAPEO, Gianluca Mariano Enrico; KRASAVIN, Mikhail Yurievitch; ORSINI, Paolo; SCOLARO, Alessandra
Patent: WO2014/64149 A1, 2014 ;
反应条件
1: sulfuric acid / water / 15 h / 150 °C 2: sodium nitrite; sulfuric acid / water / 80 °C View Scheme
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; PAPEO, Gianluca Mariano Enrico; KRASAVIN, Mikhail Yurievitch; ORSINI, Paolo; SCOLARO, Alessandra
Patent: WO2014/64149 A1, 2014 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 23 h / 20 °C
2: sodium carbonate; palladium diacetate / 1-methyl-pyrrolidin-2-one / 120 °C / |Inert atmosphere; |Sealed tube
View Scheme
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; PAPEO, Gianluca Mariano Enrico; KRASAVIN, Mikhail Yurievitch; ORSINI, Paolo; SCOLARO, Alessandra
Patent: WO2014/64149 A1, 2014 ;
