N-(β-羟乙基)-2-硝基对甲苯胺合成路线 （共 5 条）
参考文献
Hoang, Hung; LaBarbera, Daniel V.; Mohammed, Kaleem A.; Ireland, Chris M.; Skibo, Edward B.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 19 p. 4561 - 4571
参考文献
LaBarbera, Daniel V.; Skibo, Edward B.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 387 - 395
反应条件
nitric acid; acetic anhydride und Behandeln des danach isolierten Reaktionsprodukts mit methanol.Natronlauge;
参考文献
Yakugaku Zasshi, , vol. 63, p. 370,372
Chem.Abstr., , p. 2876
反应条件
1: 4-[(2'-hydroxyethyl)amino]-3-nitro-1-methylbenzene With hydrogen; palladium on activated charcoal in methanol
P=2585.74 Torr; 3 h;
2: acetic anhydride With acetic acid
1 h; Heating;
参考文献
LaBarbera, Daniel V.; Skibo, Edward B.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 387 - 395
反应条件
1.1: H2 / Pd-C / methanol / 3 h / 2585.74 Torr
1.2: 77 percent / AcOH / 1 h / Heating
2.1: 96 percent / HCl / 3 h / Heating
View Scheme
参考文献
LaBarbera, Daniel V.; Skibo, Edward B.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 387 - 395
