1: 13.5 mg / tetrabutylammonium fluoride / tetrahydrofuran / 25 h / 20 °C 2: aq. NaOH / methanol / 5 h / Ambient temperature View Scheme

Multi-step reaction with 6 steps 1.1: 82 percent / HMPA / tetrahydrofuran / 0 - 20 °C2.1: 80 percent / HF-pyridine / tetrahydrofuran; pyridine / 20 °C3.1: 89 percent / TPAP; NMO; 4 Angstroem molecular sieves / CH2Cl2 / 20 °C4.1: PPh3 / CH2Cl2 4.2: 77 percent / n-BuLi / tetrahydrofuran / 0 °C5.1: 90 percent / n-Bu4NBr; K2CO3; CuI / dimethylformamide / -20 - 20 °C6.1: 69 percent / NaBH4; H2; ethylene diamine / Ni(OAc)2*4H2O / ethanol / 20 °C