丁氧羰基-3-(1-芘基)-L-丙氨酸合成路线 （共 6 条）
反应条件
triethylamine in 1,4-dioxane; water T=0 - 20°C;
参考文献
Mihara, Hisakazu; Tanaka, Yuji; Fujimoto, Tsutomu; Nishino, Norikazu
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 6 p. 1133 - 1140
反应条件
1: 48 percent / NaOH; cobalt chloride hexahydrate; aminoacylase / H2O / 48 h / 37 °C / pH 8.0 2: 20 percent / triethylamine / H2O; dioxane / 27 h / 0 - 20 °C View Scheme
参考文献
Mihara, Hisakazu; Tanaka, Yuji; Fujimoto, Tsutomu; Nishino, Norikazu
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 6 p. 1133 - 1140
反应条件
1: 98 percent / KOH / ethanol; H2O / 18 h / Heating 2: 48 percent / NaOH; cobalt chloride hexahydrate; aminoacylase / H2O / 48 h / 37 °C / pH 8.0 3: 20 percent / triethylamine / H2O; dioxane / 27 h / 0 - 20 °C View Scheme
参考文献
Soto, Ernesto; MacDonald, John C.; Cooper, Christopher G. F.; McGimpsey, W. Grant
Journal of the American Chemical Society, 2003 , vol. 125, # 10 p. 2838 - 2839
反应条件
1: 96 percent / phosphorous tribromide / benzene / 4 h / Heating 2: 83 percent / NaH / tetrahydrofuran; ethanol / 18 h / Heating 3: 98 percent / KOH / ethanol; H2O / 18 h / Heating 4: 48 percent / NaOH; cobalt chloride hexahydrate; aminoacylase / H2O / 48 h / 37 °C / pH 8.0 5: 20 percent / triethylamine / H2O; dioxane / 27 h / 0 - 20 °C View Scheme
参考文献
Soto, Ernesto; MacDonald, John C.; Cooper, Christopher G. F.; McGimpsey, W. Grant
Journal of the American Chemical Society, 2003 , vol. 125, # 10 p. 2838 - 2839
反应条件
1: 83 percent / NaH / tetrahydrofuran; ethanol / 18 h / Heating 2: 98 percent / KOH / ethanol; H2O / 18 h / Heating 3: 48 percent / NaOH; cobalt chloride hexahydrate; aminoacylase / H2O / 48 h / 37 °C / pH 8.0 4: 20 percent / triethylamine / H2O; dioxane / 27 h / 0 - 20 °C View Scheme
参考文献
Soto, Ernesto; MacDonald, John C.; Cooper, Christopher G. F.; McGimpsey, W. Grant
Journal of the American Chemical Society, 2003 , vol. 125, # 10 p. 2838 - 2839
反应条件
1: 96 percent / aq. NaOH 2: 74 percent / CoCl2*6H2O, aq. NaOH / 48 h / 38 °C / Aspergillus genus acylase 3: 92 percent / Et3N / H2O; dioxane / 0 - 20 °C View Scheme
参考文献
Mihara, Hisakazu; Tanaka, Yuji; Fujimoto, Tsutomu; Nishino, Norikazu
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 6 p. 1133 - 1140
