3-乙酰氨基-2,4-二甲基苯酚合成路线 （共 6 条）
反应条件
iron; acetic acid beim Behandeln des Reaktionsprodukts mit wss. Schwefelsaeure und Natriumnitrit und anschliessenden Erwaermen;
反应条件
1: acetonitrile / 1.17 h / Heating 2: 70percent aq. HClO4 / acetonitrile / 0.33 h / Ambient temperature View Scheme
参考文献
Fishbein, James C.; McClelland, Robert A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 4 p. 653 - 662
反应条件
1.1: nitric acid; acetic acid; sulfuric acid / 1 h / 0 - 20 °C 2.1: palladium 10 on activated carbon; hydrogen / ethanol; methanol; acetic acid / 36 h / 20 °C 3.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C 3.2: 2 h / 100 °C View Scheme
参考文献
FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David
Patent: WO2013/37705 A2, 2013 ;
WO 2013/037705 A2
反应条件
1.1: 1 h / 0 - 20 °C 2.1: nitric acid; acetic acid; sulfuric acid / 1 h / 0 - 20 °C 3.1: palladium 10 on activated carbon; hydrogen / ethanol; methanol; acetic acid / 36 h / 20 °C 4.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C 4.2: 2 h / 100 °C View Scheme
参考文献
FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David
Patent: WO2013/37705 A2, 2013 ;
WO 2013/037705 A2
反应条件
sodium perchlorate in acetonitrile T=40°C; other 1,5-dimethyl-5-aroyloxy-6-N-acetyliminocyclohexa-1,3-dienes; var. pH; Rate constant;
参考文献
Fishbein, James C.; McClelland, Robert A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 4 p. 653 - 662
