甲酸乙酯1-(2,4-二氟苯基)-7-氯-6-氟-4-氧代羟基吡啶[2,3-B]吡啶-3-羧酸合成路线 （共 12 条）
反应条件
trichlorophosphate in diethyl ether; chloroform; water; N,N-dimethyl-formamide
参考文献
Toyama Chemical Co., Ltd.
Patent: US4704459 A1, 1987 ;
反应条件
sodium hydride in tetrahydrofuran 1 h; Heating;
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369
反应条件
1: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 2: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2364 - 2369
反应条件
1: 1.) n-BuLi, biquinoline / 1.) THF, hexane, from -30 deg C to -5 deg C, 2.) THF, hexane, RT, 1 h 2: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 3: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2364 - 2369
反应条件
1: thionyl chloride / 2 h / 80 °C 2: 1.) n-BuLi, biquinoline / 1.) THF, hexane, from -30 deg C to -5 deg C, 2.) THF, hexane, RT, 1 h 3: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 4: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2364 - 2369
反应条件
1: 73.2 percent / trifluoroacetic acid, 7.5 N aq. HCl / 24 h / Heating 2: thionyl chloride / 2 h / 80 °C 3: 1.) n-BuLi, biquinoline / 1.) THF, hexane, from -30 deg C to -5 deg C, 2.) THF, hexane, RT, 1 h 4: 1.) Ac2O / 1.) 130 deg C, 1 h, 2.) CH2Cl2, RT, 0.5 h 5: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2364 - 2369
反应条件
1: ethanol / 1 h / Ambient temperature 2: NaH / dioxane / 1 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 518 - 525
反应条件
1: ethanol / 1 h / Ambient temperature 2: NaH / dioxane / 1 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 518 - 525
反应条件
in hydrogenchloride; water
反应条件
pyridine 3 h; Ambient temperature;
参考文献
Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369
