1-乙基-6,7,8-三氟-1,4-二氢-4-氧代-3-喹啉甲酸乙酯合成路线 （共 8 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=95°C; 10 h;
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
反应条件
1: 86 percent / 2 h / Heating 2: 83 percent / various solvent(s) / 6 h / 250 °C 3: 53 percent / potassium carbonate / dimethylformamide / 10 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 63, # 9 p. 2093 - 2097
反应条件
1: 83 percent / various solvent(s) / 6 h / 250 °C 2: 53 percent / potassium carbonate / dimethylformamide / 10 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 63, # 9 p. 2093 - 2097
反应条件
1: 2 h / 110 - 120 °C 2: diphenylether / 8 h / 250 °C 3: potassium carbonate / N,N-dimethyl-formamide / 10 h / 95 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1232 - 1244
反应条件
potassium carbonate T=190°C; 1.5 h; Yield given;
参考文献
Magnetic Resonance in Chemistry, , vol. 34, # 11 p. 972 - 978
反应条件
1: With potassium carbonate in water T=90 - 95°C; 10 h; 2: With hydrogenchloride; water T=20°C; pH=7.5; 3 h;
参考文献
BERTHON-CEDILLE, Laurence; Leguern, Marie-Emmanuelle; Renaud, Gilles; Tombret, Francis
Patent: US2009/54643 A1, 2009 ;
Location in patent: Page/Page column 6 ;
反应条件
hydrogenchloride; water in acetic acid 2 h; Reflux;
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
反应条件
1: hydrogenchloride; water / acetic acid / 2 h / Reflux
2: acetonitrile / 7 h / 90 °C
View Scheme
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
