hydrogen; palladium on activated carbon in methanol; toluene T=20°C; 1.5 h; Product distribution / selectivity;

1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 15 h; Inert atmosphere;

hydrogen; palladium on activated carbon in methanol T=20°C; 1 h; Product distribution / selectivity;

1: (R)-lt;1-(1-Naphthyl)ethylgt;ammonium chloride With sodium hydroxide in toluene 2: 3-[3-(trifluoromethyl)phenyl]propanoic acid in toluene T=140 - 150°C; Further stages.;

potassium carbonate in acetonitrile 22 h; Heating / reflux;

potassium carbonate in dichloromethane T=25 - 27°C; 0.5 - 3 h; Product distribution / selectivity;

1H-1,2,4-triazol; 1,8-diazabicyclo[5.4.0]undec-7-ene in chloroform-d1 24 h; Reflux;

in ethyl acetate T=0 - 30°C; 3 h; Product distribution / selectivity;

1.1: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 15 h / 110 °C / Inert atmosphere 1.2: 15 h / 20 °C / 760.05 Torr 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 48 h / 20 °C 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere View Scheme

1: lithium hydroxide hydrate / tetrahydrofuran; water / 48 h / 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere View Scheme