6-碘咪唑并[1,2-b]吡嗪-2-胺合成路线 （共 4 条）
反应条件
Ba(OH)2·8H2O; water in 1-methyl-pyrrolidin-2-one T=120°C; 8 h;
参考文献
Miyamoto, Naoki; Sakai, Nozomu; Hirayama, Takaharu; Miwa, Kazuhiro; Oguro, Yuya; Oki, Hideyuki; Okada, Kengo; Takagi, Terufumi; Iwata, Hidehisa; Awazu, Yoshiko; Yamasaki, Seiji; Takeuchi, Toshiyuki; Miki, Hiroshi; Hori, Akira; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2333 - 2345
反应条件
hydrogenchloride in diethyl ether; ethyl acetate
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/137595 A1, 2009 ;
反应条件
in 1-methyl-pyrrolidin-2-one; di-isopropyl ether; water
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/137595 A1, 2009 ;
反应条件
1: N,N-dimethyl acetamide / 4 h / 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 30 min / 180 °C / |Microwave irradiation 3: N,N-dimethyl acetamide / 20 °C / |Cooling with ice View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 8 p. 2333 - 2345
