1: With 2,2,6,6-tetramethylpiperidinyl-lithium; (tBu)2Zn in tetrahydrofuran T=-78 - 20°C; 2: With iodine in tetrahydrofuran regioselective reaction;

copper; silver(l) oxide in N,N-dimethyl-formamide T=130°C; 15 h; Inert atmosphere;

lithium salt of proline; tetrabutylammomium bromide; potassium hydroxide; copper dichloride in water T=120°C; 0.666667 h; Microwave irradiationGreen chemistry;