5-氯-2-甲基苯并噻唑合成路线 （共 39 条）
反应条件
1.1: 92 percent / NaOH / ethane-1,2-diol / 2.5 h / Heating 2.1: potassium t-butoxide / ethanol / 1.25 h / 0 °C 2.2: 61 percent / ethanol / 2.5 h / 0 - 20 °C View Scheme
参考文献
Hodson, Stephen J.; Bishop, Michael J.; Speake, Jason D.; Navas III, Frank; Garrison, Deanna T.; Bigham, Eric C.; Saussy Jr., David L.; Liacos, James A.; Irving, Paul E.; Jeffrey Gobel; Sherman, Bryan W.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2229 - 2239
反应条件
t-Bu Brett Phos; C44H62NO5PPdS; sodium t-butanolate in 1,4-dioxane T=80°C; 20 h; Sealed tubeInert atmosphere;
参考文献
Cheung, Chi Wai; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 15 p. 3998 - 4001
反应条件
CM-phos; palladium diacetate; sodium carbonate; triethylamine in water; acetonitrile
T=70°C; 18 h;
参考文献
Yeung, Pui Yee; So, Chau Ming; Lau, Chak Po; Kwong, Fuk Yee
Organic Letters, 2011 , vol. 13, # 4 p. 648 - 651
参考文献
Freyer, Wolfgang; Fink, Frank
Zeitschrift fuer Chemie (Stuttgart, Germany), 1989 , vol. 29, # 3 p. 105 - 106
反应条件
1: concentrated HNO3; concentrated H2SO4
2: SnCl2; aq.-ethanolic HCl
3: Diazotierung und Umsetzung mit CuCl
View Scheme
参考文献
Mizuno; Adachi
Kanazawa Daigaku Yakugakubu Kenkyu Nempo, 1953 , vol. 3, p. 1,6
参考文献
Orlova; Kolchina; Shakirov; Gerasimova; Shelkovnikov
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 2 p. 228 - 231
参考文献
Orlova; Kolchina; Shakirov; Gerasimova; Shelkovnikov
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 2 p. 228 - 231
反应条件
sulfuric acid; nitric acid
参考文献
Mizuno; Adachi
Kanazawa Daigaku Yakugakubu Kenkyu Nempo, 1953 , vol. 3, p. 1,6
Full Text Show Details
Sytsch
Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1952 , vol. 18, p. 159,1611
Chem.Abstr., 1954 , p. 13685
反应条件
sulfuric acid; nitric acid
参考文献
Fridman,S.G.; Golub,D.K.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1965 , vol. 1, p. 481 - 487
Khimiya Geterotsiklicheskikh Soedinenii, 1965 , vol. 1, p. 713 - 721
