anhydrous iron chloride; methanesulfonic acid in 1,2-dichloro-ethane T=55°C; Friedel Crafts Alkylation; 16 h;

1: 3-bromo-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tert-butyl methyl ether T=-65 - -58°C; 1.5 h; 2: carbon dioxide in tert-butyl methyl ether T=-60 - -54°C; 1.5 h; 3: With hydrogenchloride; water in tert-butyl methyl ether T=-25°C; 0.0833333 h;

bismuth trifluoromethanesulphonate in 1,2-dichloro-ethane T=75°C; 16 h; Inert atmosphere;

anhydrous iron chloride in 1,2-dichloro-ethane T=70°C; Friedel Crafts Amidation; 0.25 h; Product distribution / selectivity;