3-羟基异恶唑-5-甲酸甲酯合成路线 （共 21 条）
反应条件
4-methyl-morpholine; amino-hydroxamic acid in methanol 24 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 9-10 p. 478 - 480
反应条件
triethylamine in methanol 24 h; Ambient temperaturefurther dicarboxylic acids; various bases; Product distribution;
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 9-10 p. 478 - 480
反应条件
potassium carbonate in acetone 1 h; Reflux;
参考文献
ABBOTT LABORATORIES; ABBOTT GMBH and CO.KG; MARING, Clarence J.; PRATT, John K.; CARROLL, William A.; LIU, Dachun; BETEBENNER, David A.; HUTCHINSON, Douglas K.; TUFANO, Michael D.; ROCKWAY, Todd W.; SCHOEN, Uwe; PAHL, Axel; WITTE, Adreas
Patent: WO2012/87833 A1, 2012 ;
Location in patent: Page/Page column 132-133 ;
WO 2012/087833 A1
反应条件
1: With triphenylphosphine in toluene T=20°C; Mitsunobu Displacement; 0.0333333 h; 2: With di-isopropyl azodicarboxylate in toluene T=20°C; Mitsunobu Displacement; 0.25 h; Inert atmosphere; Solvent; regioselective reaction;
参考文献
Chen, Lijia; Fletcher, Steven
Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1693 - 1696
反应条件
potassium carbonate in acetone T=70°C; 3 h;
参考文献
Riess, Regine; Schoen, Michael; Laschat, Sabine; Jaeger, Volker
European Journal of Organic Chemistry, 1998 , # 3 p. 473 - 479
反应条件
potassium carbonate in acetone T=70°C; 3 h;
参考文献
Riess, Regine; Schoen, Michael; Laschat, Sabine; Jaeger, Volker
European Journal of Organic Chemistry, 1998 , # 3 p. 473 - 479
反应条件
ammonium hydroxide 1 h;
参考文献
Jaeger; Frey
1982 , vol. No. 4, p. 817 - 820
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=-5 - 20°C; 2: With sodium hydroxide in N,N-dimethyl-formamide 4 h; 3: With hydrogenchloride in N,N-dimethyl-formamide
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; BINGGELI, Alfred; HERTEL, Cornelia; KONKAR, Anish Ashok; KUEHNE, Holger; KUHN, Bernd; MAERKI, Hans P.; WANG, Haiyan
Patent: WO2012/89601 A1, 2012 ;
Location in patent: Page/Page column 58-59 ;
WO 2012/089601 A1
反应条件
1: With methanol; sodium hydroxide T=20°C; 18 h; 2: With hydrogenchloride in water
参考文献
NOVARTIS AG
Patent: US2012/122844 A1, 2012 ;
反应条件
1: With triphenylphosphine in chloroform
T=20°C; Mitsunobu Displacement; 0.0333333 h;
2: With di-isopropyl azodicarboxylate in chloroform
T=20°C; Mitsunobu Displacement; 0.25 h; Inert atmosphere; Solvent; regioselective reaction;
参考文献
Chen, Lijia; Fletcher, Steven
Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1693 - 1696
