3-羟基异恶唑-5-甲酸甲酯合成路线 （共 21 条）
反应条件
1: methyl 3-hydroxyisoxazole-5-carboxylate With potassium carbonate in N,N-dimethyl-formamide
T=60°C; 1 h; Inert atmosphere;
2: isopropyl bromide in N,N-dimethyl-formamide
T=55°C; Inert atmosphere;
参考文献
Petersen, Jette G.; Bergmann, Rikke; Moller, Henriette A.; Jorgensen, Charlotte G.; Nielsen, Birgitte; Kehler, Jan; Frydenvang, Karla; Kristensen, Jesper; Balle, Thomas; Jensen, Anders A.; Kristiansen, Uffe; Frolund, Bente
Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 993 - 1006
