4-(4,6-二氯-5-(2-氯乙基)嘧啶-2-基)吗啉合成路线 （共 5 条）
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in water; toluene T=0 - 100°C; 7 h;
参考文献
Chugai Seiyaku Kabushiki Kaisha
Patent: EP2239261 A1, 2010 ;
Location in patent: Page/Page column 28 ;
反应条件
1: With methanol; sodium 2 h; Heating / reflux; 2: With trichlorophosphate T=100°C; 10 h; 3: With sodium hydroxide; water T=0°C;
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA
Patent: EP2050749 A1, 2009 ;
Location in patent: Page/Page column 147-148 ;
反应条件
1: sodium methylate / methanol / Reflux 2: triethyl amine hydrochloride; trichlorophosphate / toluene / 90 °C View Scheme
参考文献
Kawada, Hatsuo; Ebiike, Hirosato; Tsukazaki, Masao; Nakamura, Mitsuaki; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Ogawa, Kotaro; Shimma, Nobuo; Tsukuda, Takuo; Ohwada, Jun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 673 - 678
反应条件
1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 °C 2: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / N,N-dimethyl-formamide / 60 °C View Scheme
参考文献
Ohwada, Jun; Ebiike, Hirosato; Kawada, Hatsuo; Tsukazaki, Masao; Nakamura, Mitsuaki; Miyazaki, Takuya; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Kondoh, Osamu; Kuramoto, Shino; Ogawa, Kotaro; Aoki, Yuko; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1767 - 1772
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one T=100°C;
参考文献
Ohwada, Jun; Ebiike, Hirosato; Kawada, Hatsuo; Tsukazaki, Masao; Nakamura, Mitsuaki; Miyazaki, Takuya; Morikami, Kenji; Yoshinari, Kiyoshi; Yoshida, Miyuki; Kondoh, Osamu; Kuramoto, Shino; Ogawa, Kotaro; Aoki, Yuko; Shimma, Nobuo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1767 - 1772
