4-苯基 嘧啶-5-羧酸乙酯合成路线 （共 3 条）
反应条件
ammonium acetate; zinc(II) chloride in toluene T=100°C; 48 h; Inert atmosphere;
参考文献
Sasada, Toshiaki; Kobayashi, Fuminori; Sakai, Norio; Konakahara, Takeo
Organic Letters, 2009 , vol. 11, # 10 p. 2161 - 2164
反应条件
1: carboxamidine hydrochloride With sodium ethanolate in ethanol 0.5 h; Inert atmosphere; 2: ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate in ethanol Reflux;
参考文献
ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; BROTSCHI, Christine; KOBERSTEIN, Ralf; SIEGRIST, Romain; SIFFERLEN, Thierry; TRACHSEL, Daniel; WILLIAMS, Jodi T.
Patent: WO2010/44054 A1, 2010 ;
Location in patent: Page/Page column 137-138 ;
WO 2010/044054 A1
反应条件
1: With water; sodium hydroxide in methanol
3 h;
2: With hydrogenchloride in water
pH=1 - 2;
参考文献
ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; BROTSCHI, Christine; KOBERSTEIN, Ralf; SIEGRIST, Romain; SIFFERLEN, Thierry; TRACHSEL, Daniel; WILLIAMS, Jodi T.
Patent: WO2010/44054 A1, 2010 ;
Location in patent: Page/Page column 138 ;
WO 2010/044054 A1
