lithium hydride in N,N-dimethyl-formamide T=30 - 32°C; 48 h;

1: (S)-1-(2,4-dichlorophenyl)ethylammonium (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate With lithium amide in N,N-dimethyl-formamide 2: 2-methylsulphonyl-4,6-dimethyl-pyrimidine in N,N-dimethyl-formamide 3: Acidic conditions;

1: acetonitrile / 2 h / 20 °C / Reflux 2: lithium hydride / N,N-dimethyl-formamide / 48 h / 30 - 32 °C View Scheme