反应条件
1.1: tBuOK / dimethylformamide / 0.5 h / 20 °C
1.2: 93 percent / dimethylformamide / 3 h / 20 °C
2.1: 80 percent / aq. K2CO3; Pd(OAc)2; Bu4NBr / dioxane / 36 h / 75 °C
3.1: tetrahydrofuran / 1 h / 20 °C
4.1: 3.35 g / tetrahydrofuran / 0.42 h / 20 °C
5.1: 90 percent / aq. KOH / acetone / 1 h / 20 °C
View Scheme
参考文献
Elokdah, Hassan; Abou-Gharbia, Magid; Hennan, James K.; McFarlane, Geraldine; Mugford, Cheryl P.; Krishnamurthy, Girija; Crandall, David L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3491 - 3494