(S)-2-[5-(4-溴苯基)-1H-咪唑-2-基]吡咯烷-1-羧酸叔丁酯合成路线 (共 4 条)
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium acetate in 1,4-dioxane T=80°C; Inert atmosphere;
参考文献
MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel
Patent: WO2013/95275 A1, 2013 ;
Location in patent: Page/Page column 117 ;
反应条件
potassium acetate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=80°C; 16.5 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/50336 A1, 2008 ;
Location in patent: Page/Page column 65 ;
反应条件
potassium acetate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=80°C; 16.5 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/50336 A1, 2008 ;
Location in patent: Page/Page column 65 ;
反应条件
sodium hydrogencarbonate in ethylene glycol dimethyl ether; water
T=80°C; Suzuki-Miayura coupling; 5.75 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/44380 A1, 2008 ;
Location in patent: Page/Page column 73 ;