(S)-2-(5-溴-1H-咪唑-2-基)-吡咯烷-1-羧酸叔丁酯合成路线 （共 7 条）
反应条件
N-bromosuccinmide in dichloromethane T=-10°C; 3 h;
参考文献
TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; LAST, Stefaan Julien; HOUPIS, Ioannis Nicolaos; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2011/54834 A1, 2011 ;
Location in patent: Page/Page column 35 ;
反应条件
sodium sulfite in ethanol; water 15 h; Reflux;
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig A.; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; XU, Zaixu; SUN, Fei; JI, Tao; DAN, Zhigang
Patent: WO2012/3642 A1, 2012 ;
Location in patent: Example 3 ;
反应条件
1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; chlorine; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / 1 h / 0 °C 2: ammonia / water; methanol / 10 °C 3: N-bromosuccinmide / dichloromethane / 3 h / -10 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig A.; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; XU, Zaixu; SUN, Fei; JI, Tao; DAN, Zhigang
Patent: WO2012/3642 A1, 2012 ;
反应条件
1: ammonia / water; methanol / 10 °C 2: N-bromosuccinmide / dichloromethane / 3 h / -10 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig A.; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; XU, Zaixu; SUN, Fei; JI, Tao; DAN, Zhigang
Patent: WO2012/3642 A1, 2012 ;
反应条件
1.1: dimethylsulfide borane complex / tetrahydrofuran / 18 h / 0 - 10 °C 1.2: 0 °C 2.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; chlorine; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / 1 h / 0 °C 3.1: ammonia / water; methanol / 10 °C 4.1: N-bromosuccinmide / dichloromethane / 3 h / -10 °C View Scheme
参考文献
TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; LAST, Stefaan Julien; HOUPIS, Ioannis Nicolaos; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2011/54834 A1, 2011 ;
反应条件
1: N-bromosuccinmide / tetrahydrofuran / 20 °C / Inert atmosphere 2: sodium sulfite / ethanol; water / Reflux View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig A.; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; XU, Zaixu; SUN, Fei; JI, Tao; DAN, Zhigang
Patent: WO2012/3642 A1, 2012 ;
反应条件
1: N-bromosuccinmide / tetrahydrofuran / 20 °C / Inert atmosphere 2: sodium sulfite / ethanol; water / Reflux View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig A.; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; XU, Zaixu; SUN, Fei; JI, Tao; DAN, Zhigang
Patent: WO2012/3642 A1, 2012 ;
