4-苯基四氢呋喃-2-酮合成路线 （共 38 条）
反应条件
1: acetic acid; zinc / 7 h / 20 - 80 °C
2: dihydrogen peroxide; AcrH(+)ClO4(-) / water; acetonitrile / 20 h / 20 °C / UV-irradiation
View Scheme
参考文献
Xu, Hua-Jian; Zhu, Feng-Fei; Shen, Yong-Ya; Wan, Xin; Feng, Yi-Si
Tetrahedron, 2012 , vol. 68, # 22 p. 4145 - 4151
反应条件
1: 1.) NaH / 1.) toluene, 1 h, 2.) toluene, RT, overnight
2: 87 percent / H2 / 10percent Pd/C / acetic acid
3: 70 percent / 4 N aq. H2SO4 / dioxane / 1 h
View Scheme
参考文献
Wikstroem, Hakan; Andersson, Bengt; Sanchez, Domingo; Lindberg, Per; Arvidsson, Lars-Erik; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 215 - 225
反应条件
1: 60 percent / ethanol / 12 h / Heating
2: 1.) NaH / 1.) toluene, 1 h, 2.) toluene, RT, overnight
3: 87 percent / H2 / 10percent Pd/C / acetic acid
4: 70 percent / 4 N aq. H2SO4 / dioxane / 1 h
View Scheme
参考文献
Wikstroem, Hakan; Andersson, Bengt; Sanchez, Domingo; Lindberg, Per; Arvidsson, Lars-Erik; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 215 - 225
反应条件
1: With palladium diacetate in methanol
T=35°C; 0.75 h;
2: With boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=20°C; 24 h;
参考文献
Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Sferrazza, Alessio
Synlett, 2009 , # 6 p. 973 - 977
反应条件
(Ru2(η5-C5Ph4O)2(H)2(CO)4); Co(NMe-salpr); 2,6-dimethoxy-p-benzoquinone in chlorobenzene
T=80°C; 24 h;
参考文献
Endo, Yoshinori; Baeckvall, Jan-E.
Chemistry - A European Journal, 2011 , vol. 17, # 45 p. 12596 - 12601
反应条件
1: 87 percent / H2 / 10percent Pd/C / acetic acid
2: 70 percent / 4 N aq. H2SO4 / dioxane / 1 h
View Scheme
参考文献
Wikstroem, Hakan; Andersson, Bengt; Sanchez, Domingo; Lindberg, Per; Arvidsson, Lars-Erik; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 215 - 225
反应条件
1: With [Rh(acac)2(CO)2]; 2-isopropoxy-1-methyl-3-phenyl-2,3-dihydro-1H-benzo[d][1,3]azaphosphole; hydrogen; toluene-4-sulfonic acid in benzene
T=45°C; P=2585.81 Torr; 12 h;
2: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol
T=20°C; regioselective reaction;
参考文献
Sun; Frimpong; Tan
Journal of the American Chemical Society, 2010 , vol. 132, # 34 p. 11841 - 11843
反应条件
1: 70 percent / K2CO3, n-Bu4NCl / Pd(OAc)2 / dimethylformamide / 4 h / 60 °C
2: 93 percent / Ag2CO3/celite / toluene / 0.5 h / 80 °C
View Scheme
参考文献
Arcadi; Bernocchi; Cacchi; Marinelli
Tetrahedron, 1991 , vol. 47, # 8 p. 1525 - 1540
反应条件
1: 91 percent / air, CuCl / PdCl2
2: H(1+) / methanol
3: 1.) m-CPBA, 2.) acid
View Scheme
参考文献
Asaoka, Morio; Fujii, Naoaki; Shima, Kunihisa; Takei, Hisashi
Chemistry Letters, 1988 , # 5 p. 805 - 808
反应条件
1: 95 percent / m-CPBA
2: MeONa / Ambient temperature
3: CF3COOH / 0.02 h / Ambient temperature
4: 91 percent / air, CuCl / PdCl2
5: H(1+) / methanol
6: 1.) m-CPBA, 2.) acid
View Scheme
参考文献
Asaoka, Morio; Fujii, Naoaki; Shima, Kunihisa; Takei, Hisashi
Chemistry Letters, 1988 , # 5 p. 805 - 808
