1-苯基-1,5-二氢-4H-咪唑-4-酮合成路线 （共 3 条）
反应条件
1.1: bromine / chloroform / 20 h / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere 2.2: 1 h / 60 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere 4.1: trifluoroacetic acid / toluene / 48 h / 20 °C 5.1: triethylamine / dichloromethane / 1 h / 20 °C 6.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0); potassium bromide / 1,4-dioxane / 2 h / Inert atmosphere; Reflux View Scheme
参考文献
Arbaciauskiene, Egle; Martynaitis, Vytas; Krikstolaityte, Sonata; Holzer, Wolfgang; Sackus, Algirdas
Arkivoc, 2011 , vol. 2011, # 11 p. 1 - 21
反应条件
1.1: bromine / chloroform / 20 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere
2.2: 1 h / 60 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere
4.1: trifluoroacetic acid / toluene / 48 h / 20 °C
5.1: triethylamine / dichloromethane / 1 h / 20 °C
6.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0); potassium bromide / 1,4-dioxane / 1 h / Inert atmosphere; Reflux
View Scheme
参考文献
Arbaciauskiene, Egle; Martynaitis, Vytas; Krikstolaityte, Sonata; Holzer, Wolfgang; Sackus, Algirdas
Arkivoc, 2011 , vol. 2011, # 11 p. 1 - 21
反应条件
1: HNO3 / 0 °C
2: H2 / Pd/C
3: 42 percent / dioxane / Heating
View Scheme
参考文献
Cusan, Claudia; Spalluto, Giampiero; Prato, Maurizio; Adams, Michael; Bodensieck, Antje; Bauer, Rudolf; Tubaro, Aurelia; Bernardi, Paolo; Da Ros, Tatiana
Farmaco, 2005 , vol. 60, # 1 p. 7 - 13
