1: tert.-butylhydroperoxide / dichloromethane; chloroform; decane View Scheme

1: tert.-butylhydroperoxide / chloroform; water; decane View Scheme

1: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C 2: 97 percent / H2; aq. potassium hydrogenesulfate / Pd/C / methanol / 20 °C / 2250.18 Torr 3: diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C 4: 68 percent / diethylamine / methanol / 5 h / 60 °C View Scheme

1.1: 84 percent / triethylamine / dimethylformamide / 6 h / 100 °C 2.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -5 °C 2.2: 89 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C 3.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -20 °C 3.2: 78 percent / C2Cl6 / toluene; hexane; tetrahydrofuran / -78 - 0 °C 4.1: 57 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C View Scheme