4-(3-吗啉-4-基-丙氧基)-苯胺合成路线 （共 9 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
Location in patent: Page/Page column 136 ;
WO 2012/059932 A1
反应条件
1: With hydrogenchloride in 1,4-dioxane
T=20°C; 1 h;
2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
ARETE THERAPEUTICS, INC.
Patent: WO2008/116145 A2, 2008 ;
Location in patent: Page/Page column 76 ;
反应条件
1: 41 percent / Na2CO3; KI / acetone / Heating
2: 60 percent / NBS; PPh3 / CH2Cl2 / Heating
3: 62 percent / DMAP / tetrahydrofuran / 20 °C
4: 30 percent / Zn; aq. NH4Cl / methanol / Heating
View Scheme
参考文献
Jin, Yi; Zhou, Zu-Yu; Tian, Wei; Yu, Qiang; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5864 - 5869
反应条件
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 90 °C
2: hydrogen / palladium on activated charcoal / methanol
View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
WO 2012/059932 A1
反应条件
1: 60 percent / NBS; PPh3 / CH2Cl2 / Heating
2: 62 percent / DMAP / tetrahydrofuran / 20 °C
3: 30 percent / Zn; aq. NH4Cl / methanol / Heating
View Scheme
参考文献
Jin, Yi; Zhou, Zu-Yu; Tian, Wei; Yu, Qiang; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5864 - 5869
反应条件
1: 62 percent / DMAP / tetrahydrofuran / 20 °C
2: 30 percent / Zn; aq. NH4Cl / methanol / Heating
View Scheme
参考文献
Jin, Yi; Zhou, Zu-Yu; Tian, Wei; Yu, Qiang; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5864 - 5869
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / |Inert atmosphere
2: hydrogen; 5 palladium on charcoal / methanol / 4 h / 20 °C
View Scheme
参考文献
Pan, Xiaoyan; Wang, Fang; Zhang, Yanmin; Gao, Hongping; Hu, Zhigang; Wang, Sicen; Zhang, Jie
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2527 - 2534
参考文献
Wright; Moore
Journal of the American Chemical Society, 1954 , vol. 76, p. 4396
反应条件
1: potassium carbonate / acetonitrile / 80 °C
2: palladium 10 on activated carbon; hydrogen / methanol
View Scheme
参考文献
Song, Hyeseung; Lee, Yun Suk; Roh, Eun Joo; Seo, Jae Hong; Oh, Kwang-Seok; Lee, Byung Ho; Han, Hogyu; Shin, Kye Jung
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5668 - 5674
