(R)-(+)-2-苄氧基丙酸合成路线 （共 19 条）
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=-10°C; 2 h; Inert atmosphere; 2: With water; sodium hydroxide in diethyl ether Inert atmosphere; Further stages;
参考文献
Organic Letters, , vol. 12, # 7 p. 1496 - 1499
反应条件
1: benzyl alcohol With sodium T=80 - 90°C; 2 h; 2: (S)-α-chloropropionic acid T=55°C; 3 h; 3: With hydrogenchloride in tert-butyl methyl ether; water pH=1.5 - 6.5;
参考文献
Avecia Limited
Patent: US6362376 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
sodium hydroxide in methanol
参考文献
Wen, James J.; Crews, Craig M.
Tetrahedron Letters, 1998 , vol. 39, # 8 p. 779 - 782
反应条件
chromium(VI) oxide in pyridine; acetic acid T=23°C; 3 h; Yield given;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 62, # 8 p. 2618 - 2635
反应条件
1: 80 percent / NaH / 1,2-dimethoxy-ethane 2: 89 percent / 2N NaOH / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 8 p. 779 - 782
参考文献
Tetrahedron Letters, , vol. 27, # 16 p. 1811 - 1814
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile 2 h; Ambient temperature; Yield given;
参考文献
Tetrahedron Letters, , vol. 29, # 22 p. 2701 - 2702
反应条件
1.1: 78 percent / DCC; DMAP 2.1: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 2.2: 80 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 3.1: 98 percent / LiOH; H2O / tetrahydrofuran View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 10 p. 1835 - 1838
反应条件
1.1: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 1.2: 80 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 2.1: 98 percent / LiOH; H2O / tetrahydrofuran View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 10 p. 1835 - 1838
反应条件
1: Ti(O-iPr)4 / CH2Cl2 / 0.5 h / Ambient temperature 2: 2percent RuCl3*5H2O, NaIO4 / acetonitrile; CCl4; H2O / 2 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 22 p. 2701 - 2702
