3-溴-6-碘-2-甲基吡啶合成路线 （共 3 条）
反应条件
trimethylsilyl iodide; sodium iodide T=95°C; 16 h; Inert atmosphere;
参考文献
ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; GARCIA GARCIA, Francisco, Javier; SALAS SOLANA, Jordi
Patent: WO2013/149996 A1, 2013 ;
Location in patent: Page/Page column 68 ;
反应条件
in acetonitrile T=80°C; 16 h; Inert atmosphere;
参考文献
ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/149997 A1, 2013 ;
Location in patent: Page/Page column 55; 56 ;
反应条件
1: 3-bromo-6-iodo-2-methylpyridine With isopropylmagnesium chloride in tetrahydrofuran; dichloromethane T=-20°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; dichloromethane T=-20 - 20°C;
参考文献
Diaz, Caroline Jean; Haffner, Curt Dale; Speake, Jason Daniel; Zhang, Cunyu; Mills, Wendy Yoon; Spearing, Paul Kenneth; Cowan, David John; Green, Gary Martin
Patent: US2010/222345 A1, 2010 ;
Location in patent: Page/Page column 95 ;
