(S)-3-(甲氧基(甲基)氨基甲酰)哌啶-1-羧酸叔丁酯合成路线 (共 3 条)
反应条件
1-methyl-piperidine; chloroformic acid ethyl ester in dichloromethane T=-78 - 20°C; 4.25 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/23258 A1, 2008 ;
Location in patent: Page/Page column 46-47 ;
WO 2008/023258 A1
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; Inert atmosphere;
参考文献
AMPLA PHARMACEUTICALS INC.; HAUSKE, James, R.
Patent: WO2010/120889 A1, 2010 ;
Location in patent: Page/Page column 45; 50 ;
WO 2010/120889 A1
反应条件
in tetrahydrofuran; diethyl ether T=0°C; 2 h;
参考文献
WO2011/117254 A1, ;
Page/Page column 33 ;
WO 2011/117254 A1