(S)-(+)-1-Cbz-3-吡咯烷醇合成路线 （共 18 条）
反应条件
D-glucose; Reduced nicotinamide-adenine dinucleotide in methanol; water T=25°C; pH=8; 0.25 h; aq. potassium phosphate bufferEnzymatic reaction; Kinetics; ConcentrationReagent/catalyst; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 18 p. 3380 - 3390
参考文献
Heterocycles, , vol. 28, # 1 p. 283 - 294
反应条件
1: 1.41 g / Et3N; DMAP / CH2Cl2 / 3 h / 0 °C 2: 72 percent / dimethylsulfoxide / 4 h / 90 °C View Scheme
参考文献
Klein, Scott I.; Czekaj, Mark; Molino, Bruce F.; Valeria, Chu
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1773 - 1778
反应条件
1: pyridine / 2 h / 5 °C 2: sodium azide / dimethylformamide / 2 h / 100 °C 3: H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 4: 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme
参考文献
Sanchez; Domagala; Heifetz; Priebe; Sesnie; Trehan
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1764 - 1773
反应条件
1: pyridine / 2 h / 5 °C 2: sodium azide / dimethylformamide / 2 h / 100 °C 3: H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr View Scheme
参考文献
Sanchez; Domagala; Heifetz; Priebe; Sesnie; Trehan
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1764 - 1773
反应条件
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide in dichloromethane 2 h; Molecular sieveInert atmosphere;
参考文献
PFIZER INC.; SPRINGER, John Robert; DEVADAS, Balekudru; GARLAND, Danny James; GRAPPERHAUS, Margaret Lanahan; HAN, Seungil; HOCKERMAN, Susan Landis; HUGHES, Robert Owen; SAIAH, Eddine; SCHNUTE, Mark Edward; SELNESS, Shaun Raj; WALKER, Daniel Patrick; WAN, Zhao-Kui; XING, Li; ZAPF, Christoph Wolfgang; SCHMIDT, Michelle, Ann
Patent: WO2014/68527 A1, 2014 ;
Location in patent: Page/Page column 82 ;
反应条件
4,4'-diaminostilbene-2,2'-disulfonic acid in dichloromethane T=-78 - 20°C;
参考文献
Caldwell, Charles G.; Chen, Ping; He, Jiafang; Parmee, Emma R.; Leiting, Barbara; Marsilio, Frank; Patel, Reshma A.; Wu, Joseph K.; Eiermann, George J.; Petrov, Aleksandr; He, Huaibing; Lyons, Kathryn A.; Thornberry, Nancy A.; Weber, Ann E.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1265 - 1268
反应条件
1: NEt3, DMAP / CH2Cl2 / 2 h / 0 °C 2: 80 percent / dimethylsulfoxide / 4 h / 80 °C 3: 65 percent / HCl / methanol; H2O / 72 h / Ambient temperature View Scheme
参考文献
Klein, Scott I.; Czekaj, Mark; Molino, Bruce F.; Valeria, Chu
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1773 - 1778
