N-CBZ-3-(R)-羟基吡咯烷合成路线 （共 27 条）
反应条件
sodium carbonate in diethyl ether; water T=0 - 20°C;
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
Location in patent: Page/Page column 57 ;
反应条件
sodium hydroxide T=5°C; 2 h;
参考文献
Sanchez; Domagala; Heifetz; Priebe; Sesnie; Trehan
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1764 - 1773
反应条件
D-glucose; Sphingomonas sp. HXN-200 in phosphate buffer T=30°C; pH=7.5; 0.5 h; Enzymatic reaction;
参考文献
Li; Feiten; Chang; Duetz; Van Beilen; Witholt
Journal of Organic Chemistry, 2001 , vol. 66, # 25 p. 8424 - 8430
反应条件
sodium hydroxide in water
反应条件
sodium carbonate in water T=0 - 25°C; 4.5 h; Inert atmosphere;
参考文献
Raghuraman, Arjun; Ko, Eunhwa; Perez, Lisa M.; Ioerger, Thomas R.; Burgess, Kevin
Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12350 - 12353
反应条件
phosphate buffer in 1,4-dioxane T=25°C; 24 h; lipase PS;
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
反应条件
sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; (Ipc)2BH 1.) 0 deg C, 4 h; 2.) 25 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 108, # 8 p. 2049 - 2054
反应条件
in dichloromethane 14 h; Ambient temperature;
参考文献
Garcia-Urdiales, Eduardo; Rebolledo, Francisca; Gotor, Vicente
Tetrahedron Asymmetry, 1999 , vol. 10, # 4 p. 721 - 726
反应条件
PS-IM lipase in toluene T=20°C; 3 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Advanced Synthesis and Catalysis, , vol. 353, # 13 p. 2321 - 2327
反应条件
1: NaHCO3 / tetrahydrofuran; H2O / 2 h / Ambient temperature 2: pyridine, DMPA / CH2Cl2 / 4 h / Ambient temperature 3: 44 percent / phosphate buffer (pH 7.0) / dioxane / 24 h / 25 °C / lipase PS View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 1 p. 207 - 215
