N-CBZ-3-(R)-羟基吡咯烷合成路线 （共 27 条）
反应条件
1: pyridine, DMPA / CH2Cl2 / 4 h / Ambient temperature 2: 44 percent / phosphate buffer (pH 7.0) / dioxane / 24 h / 25 °C / lipase PS View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 1 p. 207 - 215
反应条件
D-glucose; Reduced nicotinamide-adenine dinucleotide in methanol; water T=25°C; pH=8; 0.25 h; aq. potassium phosphate bufferEnzymatic reaction; Kinetics; ConcentrationReagent/catalyst; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 18 p. 3380 - 3390
反应条件
1: 60 percent / Ph3P; DEAD / benzene / 2 h / 20 °C 2: 70 percent / dimethylsulfoxide / 4 h / 80 °C View Scheme
参考文献
Cardillo, Giuliana; Gentilucci, Luca; Melchiorre, Paolo; Spampinato, Santi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2755 - 2758
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene; Xtalfluor-E® in dichloromethane T=-78 - 20°C; 24.5 h; Inert atmosphere; 2: With water; sodium hydrogencarbonate in dichloromethane T=20°C; 0.25 h;
参考文献
OMEGACHEM INC.; COUTURIER, Michel; L'HEUREUX, Alexandre
Patent: WO2010/145037 A1, 2010 ;
Location in patent: Page/Page column 48-49 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; Xtalfluor-E® in dichloromethane T=-78 - 20°C; 24 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Lheureux, Alexandre; Beaulieu, Francis; Bennett, Christopher; Bill, David R.; Clayton, Simon; Laflamme, Franois; Mirmehrabi, Mahmoud; Tadayon, Sam; Tovell, David; Couturier, Michel
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3401 - 3411
反应条件
1: 91 percent / pyridine / 2 h / 5 °C 2: 98 percent / sodium azide / dimethylformamide / 2 h / 100 °C 3: 95 percent / H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr View Scheme
参考文献
Sanchez; Domagala; Heifetz; Priebe; Sesnie; Trehan
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1764 - 1773
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane Swern oxidation;
参考文献
MERCK and CO., INC.
Patent: WO2004/43940 A1, 2004 ;
Location in patent: Page 48 ;
反应条件
1: With trifluoroacetic acid sodium salt; 2,2-difluoro-1,3-dimethylimidazollidine in toluene T=0 - 50°C; 4 h; 2: With water; sodium hydrogencarbonate in toluene T=15 - 20°C; 0.5 h; Product distribution / selectivity;
参考文献
Mitsui Chemicals, Inc.
Patent: EP2039680 A1, 2009 ;
Location in patent: Page/Page column 43 ;
反应条件
1: (COCl)2; DMSO; Et3N / CH2Cl2 2: [bis(2-methoxyethyl)amino]sulfur trifluoride / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Caldwell, Charles G.; Chen, Ping; He, Jiafang; Parmee, Emma R.; Leiting, Barbara; Marsilio, Frank; Patel, Reshma A.; Wu, Joseph K.; Eiermann, George J.; Petrov, Aleksandr; He, Huaibing; Lyons, Kathryn A.; Thornberry, Nancy A.; Weber, Ann E.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1265 - 1268
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C; 3 h;
参考文献
Cardillo, Giuliana; Gentilucci, Luca; Melchiorre, Paolo; Spampinato, Santi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2755 - 2758
