R-1-cbz-3-羟基-哌啶合成路线 （共 8 条）
反应条件
sodium hydroxide; sodium hydrogencarbonate in water; toluene Ambient temperature;
参考文献
Huh, Nam; Thompson, Charles M.
Tetrahedron, 1995 , vol. 51, # 21 p. 5935 - 5950
反应条件
phosphate buffer in 1,4-dioxane T=25°C; 90 h; lipase PS;
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
反应条件
1: BH3 / tetrahydrofuran / 6 h / 20 °C 2: 40 percent / aq. Na2CO3 / tetrahydrofuran / 6 h / 0 °C View Scheme
参考文献
Monterde, Maria I.; Nazabadioko, Serge; Rebolledo, Francisca; Brieva, Rosario; Gotor, Vicente
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3449 - 3455
反应条件
1: 96 percent / NaHCO3 / tetrahydrofuran; H2O; toluene / Ambient temperature 2: 99 percent / toluene / 5.5 h / 100 °C 3: 50 percent / phosphate buffer / dioxane / 90 h / 25 °C / lipase PS View Scheme
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
反应条件
1: 96 percent / NaHCO3 / tetrahydrofuran; H2O; toluene / Ambient temperature 2: 99 percent / toluene / 5.5 h / 100 °C 3: 50 percent / phosphate buffer / dioxane / 90 h / 25 °C / lipase PS View Scheme
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
反应条件
1: 99 percent / toluene / 5.5 h / 100 °C 2: 50 percent / phosphate buffer / dioxane / 90 h / 25 °C / lipase PS View Scheme
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Brown, Herbert C.; Prasad, J. V. N. Vara
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2049 - 2054
反应条件
hydrogen; palladium on activated charcoal
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
