3-甲氧基-4-甲基苯乙酸合成路线 （共 7 条）
反应条件
sodium hydroxide; water in ethanol 20 h; Heating / reflux;
参考文献
WELLSTAT THERAPEUTICS CORPORATION; SHARMA, Shalini; O'NEIL, James, Dennen; VON BORSTEL, Reid, W.; ARUDCHANDRAN, Ramchandran
Patent: WO2011/46800 A1, 2011 ;
Location in patent: Page/Page column 84 ;
WO 2011/046800 A1
反应条件
1: 1,4-dimethyl-2-methoxybenzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane T=-78°C; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran; hexane Inert atmosphere; regioselective reaction;
参考文献
Fleming, Patricia; Oshea, Donal F.
Journal of the American Chemical Society, 2011 , vol. 133, # 6 p. 1698 - 1701
反应条件
sulfuric acid; acetic acid
参考文献
Beasley,J.G.; Burger,A.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 686 - 689
反应条件
1: (i) SOCl2, benzene, (ii) aq. NH3 2: LiAlH4 View Scheme
参考文献
Beasley,J.G.; Burger,A.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 686 - 689
反应条件
1: With borane-THF in tetrahydrofuran 18 h; 2: With methanol in tetrahydrofuran
参考文献
ABBOTT LABORATORIES
Patent: WO2008/79382 A1, 2008 ;
Location in patent: Page/Page column 126-127 ;
WO 2008/079382 A1
反应条件
bromine in acetic acid
T=20°C; 3 h; Inert atmosphere;
参考文献
Lopez-Tapia, Francisco Javier; Murray Walker, Keith Adrian; Zhao, Shu-Hai
Patent: US2010/160387 A1, 2010 ;
Location in patent: Page/Page column 27 ;
US 20100160387 A1
反应条件
(i) SOCl2, benzene, (ii) aq. NH3; Multistep reaction;
参考文献
Beasley,J.G.; Burger,A.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 686 - 689
